Supplemental therapy for diabetes: a necessity or an additional choice?

Saienko Y. A., Shapovalenko I. S., Mankovsky B. M.
D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv

DOI : https://doi.org/10.57105/2415-7252-2024-2-01

Abstract

Diabetes mellitus (DM) is a chronic endocrine and metabolic disease that occurs as a result of absolute or relative insulin deficiency under the influence of a combination of genetic and exogenous factors. Effective management of DM includes drug therapy, lifestyle modification, and psychological support. Particular attention is paid to the assessment of micronutrient status and its role in the development of diabetes and complications.

The article presents an analysis of current recommendations for the use of supplemental therapy drugs as an effective addition to standard DM therapy. The need to take into account the quality of dietary supplements and the evidence base for their use is emphasized.

References:
  1. Міністерство охорони здоров’я України. Цукровий діабет 2 типу: Уніфікований клінічний протокол первинної та спеціалізованої медичної допомоги, затверджений наказом МОЗ України від 24 липня 2024 р. No 1300. Київ: МОЗ України; 2024. Доступно за: https:// www.dec.gov.ua/mtd/czukrovyj-diabet-2-typu.
  2. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022 Jan;183:109119. doi: 10.1016/j.diabres.2021.109119. Epub 2021 Dec 6. PMID: 34879977; PMCID: PMC11057359.
  3. Міністерство охорони здоров’я України. У пів мільйона українців діагностовано цукровий діабет у 2023 році. Київ: МОЗ України; 2023. Доступно за: https://moz.gov. ua/uk/u-piv-miljona-ukrainciv-diagnostovano-cukrovij- diabet-u-2023-roci
  4. Odgers-Jewell K., Ball L.E., Kelly J.T., Isenring E.A., Reidlinger, D. P., Thomas R. Effectiveness of group-based self-management education for individuals with Type 2 diabetes: a systematic review with meta-analyses and meta-regression. Diabetic Medicin. 2017 Aug; 34(8):1027-1039. DOI: 10.1111/dme.13340
  5. Chen S, Jin, X, Shan Z, Li S, Yin J, Sun T, Luo C, Yang W, Yao P., Yu K, Zhang Y, Cheng Q, Cheng J, Bao W, Liu L. Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study. Nutrients. 2017 Mar; 9(3):294. DOI: 10.3390/nu9030294
  6. Landman GW, Bilo HJ, Houweling ST, Kleefstra N. Chromium does not belong in the diabetes treatment arsenal: Current evidence and future perspectives. World J Diabetes. 2014 Apr;5(2):160-4. DOI: 10.4239/wjd.v5.i2.160
  7. Sami W, Ansari T, Butt NS, Hamid MRA. Effect of diet on type 2 diabetes mellitus: A review. Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):65-71. PMCID: PMC5426415 PMID: 28539866
  8. Asbaghi O, Fatemeh N, Mahnaz RK, Ehsan G, Elham E, Behzad N, Damoon AL, Amirmansour AN. Effects of chromium supplementation on glycemic control in pa- tients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2020 Nov;161:105098. doi: 10.1016/j.phrs.2020.105098
  9. Fatima Alkhalidi. A comparative study to assess the use of chromium in type 2 diabetes mellitus. J Med Life. 2023 Aug; 16 (8): 1178-1182. Doi: 10.25122/jml-2023-0081.
  10. Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetology & Metabolic Syndrome. 2012; 4(1): 13. DOI: 10.1186/1758-5996-4-13
  11. El-Ashmony SMA, Morsi HK, Abdelhafez AM. Effect of Zinc Supplementation on Glycemic Control, Lipid Profile, and Renal Functions in Patients with Type II Diabetes: A Single Blinded, Randomized, Placebo-Controlled, Trial. Journal of Biology, Agriculture and Healthcare. 2012; 12(6): 33-42
  12. Chabosseau P, Rutter GA. Zinc and diabetes. Archives of Biochemistry and Biophysics. 2016 Dec; 611: 79-85. https:// doi.org/10.1016/j.abb.2016.05.022
  13. Holick MF. Vitamin D Deficiency. New England Journal of Medicine. 2007; 357(3): 266–281. https://doi.org/10.1056/ nejmra070553
  14. Maddaloni E, Cavallari I, Napoli N, Conte C. Vitamin D and Diabetes Mellitus. Front Horm Res. 2018 Mar; 50:161-176. doi: 10.1159/000486083
  15. Angellotti E, D’Alessio D, Dawson-Hughes B, Chu Y, Nelson J, Hu P, Cohen RM, Pittas AG. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clinical Nutrition. 2019 Oct; 38(5):2449-2453. doi: 10.1016/j. clnu.2018.10.003
  16. Pittas AG, Kawahara T, Jorde R, Dawson-Hughes B, Vickery EM, Angellotti E, Nelson J, Trikalinos TA, Balk EM. Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials. Ann Intern Med. 2023 Mar;176(3):355-363. doi: 10.7326/M22-3018
  17. Seeram NP. Berry fruits for cancer prevention: Current status and future prospects. Journal of Agricultural and Food Chemistry. 2008; 56(3):630–635. https://doi.org/10.1021/ jf072504n
  18. McDougall GJ, Kulkarni NN, Stewart D. Current developments on the inhibitory activity effects of berry polyphenols on digestive enzymes. BioFactors. 2008; 34(1): 73–80. https://doi.org/10.1002/biof.5520340108
  19. Vuong T, Benhaddou-Andaloussi A, Brault A, Harbilas D, Martineau LC, Vallerand D, Ramassamy C, Matar C, Haddad PS. Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA y mice. International Journal of Obesity. 2009; 33(10):1166–1173. DOI: 10.1038/ ijo.2009.149
  20. Li H, Xia N, Brausch I, Yao Y, Förstermann U. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. Journal of Pharmacology and Experimental Therapeutics. 2004; 310(3): 926–932. https://doi.org/10.1124/ jpet.104.066639
  21. Fantini N, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MAM. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytotherapy Research. 2011; 25:463–466. DOI: 10.1002/ptr.3285
  22. Rondanelli M, Riva A, Petrangolini G, Allegrini P, Bernardinelli L, Fazia T, Peroni G, Gasparri C, Nichetti M, Faliva M A, Naso M, Perna S. The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Nutrients. 2020 Oct; 12(11):3298. DOI: 10.3390/nu12113298
  23. Rondanelli, M, Castellazzi AM, Riva A, Allegrini P, Faliva MA, Peroni G, Naso M, Nichetti M, Tagliacarne C, Valsecchi C, Fazia T, Perna S, Graziano F, Grassi M, Bernardinelli L. Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation. Evidence-Based Complementary and Alternative Medicine. 2019 Jan; 1-9. DOI: 10.1155/2019/2069701
  24. Scientific Opinion on the substantiation of a health claim related to the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-α-tocopheryl hydrogen succinate, riboflavin and inositol hexanicotinate in Limicol® and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2013;11(7):3327. https://doi.org/10.2903/j.efsa.2013.3327
  25. The Role of Dietary Anthocyanins for Managing Diabetes. Mellitus-Associated Complications. Priya S. Mistry, etal. P. 76-99. Current Diabetes Reviews, 2025, Vol. 21, No. 9.
PDF (українська)

Published
2025

How to Cite

Saienko Y. A., Shapovalenko I. S., Mankovsky B. M. (2025). Supplemental therapy for diabetes: a necessity or an additional choice? Diabetes Obesity Metabolic Syndrome. 2(14), 47-52.