Doms № 6 -2023

Реалізація протоколів прискореного післяопераційного відновлення у хворих
із метаболічним синдромом в абдомінальній хірургії (огляд літератури)

Тодуров І. М., Плегуца О. І., Перехрестенко О. В., Косюхно С. В.,

Калашніков О. О., Троц А. В., Кирик В. О., Гриневич А. А.

https://doi.org/10.57105/2415-7252-2023-6-01

 

Резюме

Прагнення до стандартизації методів периопераційного ведення хворих спонукали до створення відповідних алгоритмів. Стрімкий розвиток сучасної хірургії, впровадження малоінвазивних оперативних методик, удосконалення анестезіологічної служби, а також розстановка акцентів на поглиблення в патофізіологічні процеси того чи іншого захворювання значно сприяли досягненню максимальної результативності лікування та безпеки пацієнтів. Так розпочалась ера впровадження в практику протоколів прискореного післяопераційного відновлення хворих (ERAS). Водночас, така тактика, в певних випадках, не враховувє індивідуальних супутніх станів у хворих, що можуть ускладнити перебіг периопераційного періоду та поставити під загрозу життя та здоров’я пацієнта. Метаболічний синдром є саме таким станом, неврахування якого є легковажним з боку лікаря, оскільки зі значно більшими ризиками може провокувати розвиток серцево-судинних, респіраторних, інфекційних та інших ускладнень, що погіршує прогнози лікування, а також збільшує економічні витрати на лікуван- ня таких пацієнтів. Парадоксальність полягає у тому, що незважаючи на його значну поширеність у світовій популяції, існує відносно небагато наукових праць, де досліджується влив метаболічного синдрому на перебіг периопераційного періоду в контексті ERAS. Враховуючи частоту поширення даного стану серед популяції та наявність прихованих форм метаболічних порушень, метаболічний синдром, однозначно, заслуговує додаткової умаси тіла з боку лікаря та, можливо, потребує проведення додаткових досліджень щодо розробки та впровадження нових стратегій протоколів пришвидшеного післяопераційного відновлення з урахуванням даної патології у довгостроковій перспективі.

У цій статті представлено основні компоненти протоколів ERAS в колоректальній та абдомі- нальній хірургії з акцентом на особливості їх реалізації у пацієнтів з метаболічним синдромом. Зокрема, надаються певні деталі як хірургічного, так і анестезіологічного шляхів ERAS в аспекті передоперацій- ного, післяопераційного та післяопераційного догляду.

Ключові слова: метаболічний синдром, ожиріння, цукровий діабет, протоколи прискореного після- операційного відновлення, ERAS, раннє післяопераційне відновлення.

Implementation of enhanced recovery after surgery (ERAS) protocols in patients

with metabolic syndrome in abdominal surgery

Todurov IM, Plehutsa OI, Perekhrestenko OV, Kosiukhno SV, Kalashnikov OO, Trots AV, Kyryk VO, Hrynevych AA

Abstract

Efforts to standardize methods of perioperative management of patients prompted the creation of appropriate algorithms. The rapid development of modern surgery, the introduction of minimally invasive surgical techniques, the improvement of anesthesiological services, and also the placing of emphasis on the deepening of pathophysiological processes, which are important for achieving the maximum effectiveness of treatment and patient safety. Thus began the era of implementation of enhanced recovery after surgery (ERAS) protocols on the practice. At the same time, such tactics, in certain cases, do not take into account individual concomitant conditions of patients, which can complicate the course of the perioperative period and endanger the life and health of the patient. Metabolic syndrome is just such a condition, the neglect of which is frivolous on the part of the doctor, because with much greater risks it can provoke the development of cardiovascular, respiratory, infectious and other complications, which worsens the prognosis of treatment and also increases the economic costs of treating such patients. The paradox is that, despite its significant prevalence in the world population, there are relatively few scientific works investigating the influence of metabolic syndrome on the course of the perioperative period in the context of ERAS. Considering the prevalence of this condition among the population and the presence of hidden forms of metabolic disorders, the metabolic syndrome clearly deserves additional attention from the doctor and may require additional research on the development and implementation of new strategies for enhanced recovery after surgery protocols taking into account this pathology in the long term. This article presents the main components of ERAS protocols in colorectal and general abdominal surgery with an emphasis on the specifics of their implementation in patients with metabolic syndrome. In particular, specific details of both the surgical and anesthetic pathways of ERAS are provided in terms of preoperative, postoperative, and postoperative care.

Key words: metabolic syndrome, obesity, diabetes, enhanced recovery after surgery protocols, ERAS, early postoperative recovery

 

 

References

  1. Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., … Smith, S. C. (2009). Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 120(16), 1640–1645. doi:10.1161/circulationaha.109.192644
  2. Rochlani, Y., Pothineni, N. V., Kovelamudi, S., & Mehta, J. L. (2017). Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Therapeutic Advances in Cardiovascular Disease, 11(8), 215–225. doi:10.1177/1753944717711379
  3. WHO GlobalHealthObservatoryDataRepository [onlinedatabase]. Geneva, WorldHealthOrganization, 2013 (http://apps.who.int/gho/data/view.main, accessed 21 May 2013)
  4. Lee IT, Chiu YF, Hwu CM, He CT, Chiang FT, Lin YC, Assimes T, Curb JD, Sheu WH. Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study. Cardiovasc Diabetol. 2012 Apr 26;11:43. doi: 10.1186/1475-2840-11-43.
  5. Coelho CCNDS, Bragança MLBM, de Oliveira BR, Bettiol H, Barbieri MA, Cardoso VC, Silva AAMD. Incidence of metabolic syndrome in adults with healthy weight, normal weight obesity, and overweight/obesity. Nutrition. 2021 May;85:111134. doi: 10.1016/j.nut.2020.11113
  6. Suliga E, Kozieł D, Głuszek S. Prevalence of metabolic syndrome in normal weight individuals. Ann Agric Environ Med. 2016 Dec 23;23(4):631-635. doi: 10.5604/12321966.1226858.
  7. Mohammadian Khonsari N, Khashayar P, Shahrestanaki E, Kelishadi R, Mohammadpoor Nami S, Heidari-Beni M, Esmaeili Abdar Z, Tabatabaei-Malazy O, Qorbani M. Normal Weight Obesity and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2022 Mar 24;13:857930. doi: 10.3389/fendo.2022.857930.
  8. Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., … Shimomura, I. (2004). Increased oxidative stress in obesity and its impact on metabolic syndrome. Journal of Clinical Investigation, 114(12), 1752–1761. doi:10.1172/jci21625
  9. Khaing, P., Pandit, P., Awsare, B., & Summer, R. (2019). Pulmonary Circulation in Obesity, Diabetes, and Metabolic Syndrome. Comprehensive Physiology, 297–316. doi:10.1002/cphy.c190018
  • Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Netw Open. 2021 Dec 1;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568.
  • Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., … Eisenberg, M. J. (2010). The Metabolic Syndrome and Cardiovascular Risk. Journal of the American College of Cardiology, 56(14), 1113–1132. doi:10.1016/j.jacc.2010.05.034
  • Kachur, S., Morera, R., De Schutter, A., & Lavie, C. J. (2018).Cardiovascular Risk in Patients with Prehypertension and the Metabolic Syndrome. Current Hypertension Reports, 20(2). doi:10.1007/s11906-018-0801-2
  • Zhang X, Lerman LO. The metabolic syndrome and chronic kidney disease. Transl Res. 2017 May;183:14-25. doi: 10.1016/j.trsl.2016.12.004.
  • Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease. Int J Mol Sci. 2021 Aug 26;22(17):9221. doi: 10.3390/ijms22179221.
  • Shen X, Wang Y, Zhao R, Wan Q, Wu Y, Zhao L, Wu X. Metabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis. Int J Colorectal Dis. 2021 Oct;36(10):2215-2225. doi: 10.1007/s00384-021-03974-y.
  • Xian YX, Weng JP, Xu F. MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy. Chin Med J (Engl). 2020 Dec 14;134(1):8-19. doi: 10.1097/CM9.0000000000001263.
  • Shariq OA, Hanson KT, McKenna NP, Kelley SR, Dozois EJ, Lightner AL, Mathis KL, Habermann EB. Does Metabolic Syndrome Increase the Risk of Postoperative Complications in Patients Undergoing Colorectal Cancer Surgery? Dis Colon Rectum. 2019 Jul;62(7):849-858. doi: 10.1097/DCR.0000000000001334.
  • Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997 May;78(5):606-17. doi: 10.1093/bja/78.5.606.
  • Smith TW Jr, Wang X, Singer MA, Godellas CV, Vaince FT. Enhanced recovery after surgery: A clinical review of implementation across multiple surgical subspecialties. Am J Surg. 2020 Mar;219(3):530-534. doi: 10.1016/j.amjsurg.2019.11.009.
  • Ljungqvist O, Scott M, Fearon KC. Enhanced Recovery After Surgery: A Review. JAMA Surg. 2017 Mar 1;152(3):292-298. doi: 10.1001/jamasurg.2016.4952.
  • Shao JM, Deerenberg EB, Prasad T, Dunphy C, Colavita PD, Augenstein VA, Heniford BT. Adoption of enhanced recovery after surgery and intraoperative transverse abdominis plane block decreases opioid use and length of stay in very large open ventral hernia repairs. Am J Surg. 2021 Oct;222(4):806-812. doi: 10.1016/j.amjsurg.2021.02.025.
  • Sartori A, Botteri E, Agresta F, Gerardi C, Vettoretto N, Arezzo A, Pisanu A, Di Saverio S, Campanelli G, Podda M. Should enhanced recovery after surgery (ERAS) pathways be preferred over standard practice for patients undergoing abdominal wall reconstruction? A systematic review and meta-analysis. Hernia. 2021 Apr;25(2):501-521. doi: 10.1007/s10029-020-02262-y.
  • Koivisto JM, Saarinen I, Kaipia A, Puukka P, Kivinen K, Laine KM, Haavisto E. Patient education in relation to informational needs and postoperative complications in surgical patients. Int J Qual Health Care. 2020 Apr 21;32(1):35-40. doi: 10.1093/intqhc/mzz032.
  • Przybycien-Gaweda PM, Gwee X, Gao Q, Chua DQL, Fam J, Ng TP. Metabolic Syndrome and Cognition: Follow-Up Study of Chinese Over-55-Year-Olds. Dement Geriatr Cogn Disord. 2020;49(2):129-137. doi: 10.1159/000509124.
  • Wongkietkachorn A, Wongkietkachorn N, Rhunsiri P. Preoperative Needs-Based Education to Reduce Anxiety, Increase Satisfaction, and Decrease Time Spent in Day Surgery: A Randomized Controlled Trial. World J Surg. 2018 Mar;42(3):666-674. doi: 10.1007/s00268-017-4207-0.
  • Smilowitz, N. R., & Berger, J. S. (2020). Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery. JAMA, 324(3), 279. doi:10.1001/jama.2020.7840
  • Waterland JL, McCourt O, Edbrooke L, Granger CL, Ismail H, Riedel B, Denehy L. Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis. Front Surg. 2021 Mar 19;8:628848. doi: 10.3389/fsurg.2021.628848.
  • Barberan-Garcia, A., Ubré, M., Roca, J., Lacy, A. M., Burgos, F., Risco, R., Martínez-Pallí, G. (2018). Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery. Annals of Surgery, 267(1), 50– doi:10.1097/sla.0000000000002293
  • Kanemoto M, Ida M, Naito Y, Kawaguchi M. The impact of preoperative nutrition status on abdominal surgery outcomes: A prospective cohort study. Nutr Clin Pract. 2022 Nov 29. doi: 10.1002/ncp.10932.
  • Melguizo-Rodríguez L, Costela-Ruiz VJ, García-Recio E, De Luna-Bertos E, Ruiz C, Illescas-Montes R. Role of Vitamin D in the Metabolic Syndrome. Nutrients. 2021 Mar 3;13(3):830. doi: 10.3390/nu13030830.
  • Gupta A, Gupta E, Hilsden R, Hawel JD, Elnahas AI, Schlachta CM, Alkhamesi NA. Preoperative malnutrition in patients with colorectal cancer. Can J Surg. 2021 Nov 25;64(6):E621-E629. doi: 10.1503/cjs.016820.
  • González-Domínguez Á, Visiedo-García FM, Domínguez-Riscart J, González-Domínguez R, Mateos RM, Lechuga-Sancho AM. Iron Metabolism in Obesity and Metabolic Syndrome. Int J Mol Sci. 2020 Aug 1;21(15):5529. doi: 10.3390/ijms21155529.
  • Gan, T. J., Belani, K. G., Bergese, S., Chung, F., Diemunsch, P., Habib, A. S., … Philip, B. K. (2020). Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anesthesia & Analgesia, Publish Ahead of Print. doi:10.1213/ane.000000000000483
  • (2017). Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial). BMJ, j1455. doi:10.1136/bmj.j1455
  • Grant MC, Lee H, Page AJ, Hobson D, Wick E, Wu CL. The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesth Analg. 2016 Apr;122(4):976-85. doi: 10.1213/ANE.0000000000001120.
  • Apfel CC, Turan A, Souza K, Pergolizzi J, Hornuss C. Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis. Pain. 2013 May;154(5):677-689. doi: 10.1016/j.pain.2012.12.025.
  • Rajan S, Rahman AA, Kumar L. Preoperative oral carbohydrate loading: Effects on intraoperative blood glucose levels, post-operative nausea and vomiting, and intensive care unit stay. J Anaesthesiol Clin Pharmacol. 2021 Oct-Dec;37(4):622-627. doi: 10.4103/joacp.JOACP_382_19.
  • Chen YK, Soens MA, Kovacheva VP. Less stress, better success: a scoping review on the effects of anxiety on anesthetic and analgesic consumption. J Anesth. 2022 Aug;36(4):532-553. doi: 10.1007/s00540-022-03081-4.
  • Madsen BK, Zetner D, Møller AM, Rosenberg J. Melatonin for preoperative and postoperative anxiety in adults. Cochrane Database Syst Rev. 2020 Dec 8;12(12):CD009861. doi: 10.1002/14651858.CD009861.pub3.
  • Shariq OA, Hanson KT, McKenna NP, Kelley SR, Dozois EJ, Lightner AL, Mathis KL, Habermann EB. Does Metabolic Syndrome Increase the Risk of Postoperative Complications in Patients Undergoing Colorectal Cancer Surgery? Dis Colon Rectum. 2019 Jul;62(7):849-858. doi: 10.1097/DCR.0000000000001334.
  • Chen, M., Song, X., Chen, L., Lin, Z., & Zhang, X. (2016). Comparing Mechanical Bowel Preparation With Both Oral and Systemic Antibiotics Versus Mechanical Bowel Preparation and Systemic Antibiotics Alone for the Prevention of Surgical Site Infection After Elective Colorectal Surgery. Diseases of the Colon & Rectum, 59(1), 70–78. doi:10.1097/dcr.0000000000000524
  • Zhang, D., Wang, X.-C., Yang, Z.-X., Gan, J.-X., Pan, J.-B., & Yin, L.-N. (2017). Preoperative chlorhexidine versus povidone-iodine antisepsis for preventing surgical site infection: A meta-analysis and trial sequential analysis of randomized controlled trials. International Journal of Surgery, 44, 176–184. doi:10.1016/j.ijsu.2017.06.001
  • Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration. (2017). Anesthesiology, 126(3), 376–393. doi:10.1097/aln.0000000000001452
  • Gianotti, L., Biffi, R., Sandini, M., Marrelli, D., Vignali, A., Caccialanza, R., … Bernasconi, D. P. (2018). Preoperative Oral Carbohydrate Load Versus Placebo in Major Elective Abdominal Surgery (PROCY). Annals of Surgery, 267(4), 623–630. doi:10.1097/sla.000000000000232
  • Jung CH, Choi KM. Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes. Nutrients. 2017 Mar 24;9(4):322. doi: 10.3390/nu9040322.
  • Lewis SR, Pritchard MW, Fawcett LJ, Punjasawadwong Y. Bispectral index for improving intraoperative awareness and early postoperative recovery in adults. Cochrane Database Syst Rev. 2019 Sep 26;9(9):CD003843. doi: 10.1002/14651858.CD003843.pub4.
  • Kendrick JB, Kaye AD, Tong Y, Belani K, Urman RD, Hoffman C, Liu H. Goal-directed fluid therapy in the perioperative setting. J Anaesthesiol Clin Pharmacol. 2019 Apr;35(Suppl 1):S29-S34. doi: 10.4103/joacp.JOACP_26_18.
  • Lau, A., Lowlaavar, N., Cooke, E. M., West, N., German, A., Morse, D. J., … Merchant, R. N. (2018). Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial. Canadian Journal of Anesthesia/Journal Canadien D’anesthé doi:10.1007/s12630-018-1161-8
  • Song XJ, Liu ZL, Zeng R, Ye W, Liu CW. A meta-analysis of laparoscopic surgery versus conventional open surgery in the treatment of colorectal cancer. Medicine (Baltimore). 2019 Apr;98(17):e15347. doi: 10.1097/MD.0000000000015347.
  • Wang X, Cao G, Mao W, Lao W, He C. Robot-assisted versus laparoscopic surgery for rectal cancer: A systematic review and meta-analysis. J Cancer Res Ther. 2020 Sep;16(5):979-989. doi: 10.4103/jcrt.JCRT_533_18.
  • Song Z, Liu K, Zhang T, Wang B, Shi Y, Jiang Y, Wang C, Chen X, Ji X, Zhao R. Oncologic outcomes of single-incision laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer (CSILS): study protocol for a multicentre, prospective, open-label, noninferiority, randomized controlled trial. BMC Cancer. 2022 Jul 7;22(1):743. doi: 10.1186/s12885-022-09821-9.
  • Zarzavadjian Le Bian A, Denet C, Tabchouri N, Levard H, Besson R, Perniceni T, Costi R, Wind P, Fuks D, Gayet B. The effect of metabolic syndrome on postoperative outcomes following laparoscopic colectomy. Tech Coloproctol. 2018 Mar;22(3):215-221. doi: 10.1007/s10151-018-1772-7.
  • Stenberg E, Dos Reis Falcão LF, O’Kane M, Liem R, Pournaras DJ, Salminen P, Urman RD, Wadhwa A, Gustafsson UO, Thorell A. Guidelines for Perioperative Care in Bariatric Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations: A 2021 Update. World J Surg. 2022 Apr;46(4):729-751. doi: 10.1007/s00268-021-06394-9. Epub 2022 Jan 4. Erratum in: World J Surg. 2022 Jan 29;:
  • Emile SH, Abd El-Hamed TM. Routine Drainage of Colorectal Anastomoses: An Evidence-Based Review of the Current Literature. Gastroenterol Res Pract. 2017;2017:6253898. doi: 10.1155/2017/6253898.
  • Albendary M, Mohamedahmed AYY, George A. Delayed Adult Gastric Perforation Following Insertion of a Feeding Nasogastric Tube. Cureus. 2021 Nov 9;13(11):e19411. doi: 10.7759/cureus.19411.
  • Chia PA, Cannesson M, Bui CCM. Opioid free anesthesia: feasible? Curr Opin Anaesthesiol. 2020 Aug;33(4):512-517. doi: 10.1097/ACO.0000000000000878.
  • Ilfeld BM, Eisenach JC, Gabriel RA. Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain. Anesthesiology. 2021 Feb 1;134(2):283-344. doi: 10.1097/ALN.0000000000003630.
  • Radovanović D, Radovanović Z, Škorić-Jokić S, Tatić M, Mandić A, Ivković-Kapicl T. Thoracic Epidural Versus Intravenous Patient-Controlled Analgesia after Open Colorectal Cancer Surgery. Acta Clin Croat. 2017 Jun;56(2):244-254. doi: 10.20471/acc.2017.56.02.07.
  • Helander EM, Webb MP, Bias M, Whang EE, Kaye AD, Urman RD. Use of Regional Anesthesia Techniques: Analysis of Institutional Enhanced Recovery After Surgery Protocols for Colorectal Surgery. J Laparoendosc Adv Surg Tech A. 2017 Sep;27(9):898-902. doi: 10.1089/lap.2017.0339.
  • Peltrini R, Cantoni V, Green R, Greco PA, Calabria M, Bucci L, Corcione F. Efficacy of transversus abdominis plane (TAP) block in colorectal surgery: a systematic review and meta-analysis. Tech Coloproctol. 2020 Aug;24(8):787-802. doi: 10.1007/s10151-020-02206-9.
  • Emoto S, Nozawa H, Kawai K, Hata K, Tanaka T, Shuno Y, Nishikawa T, Sasaki K, Kaneko M, Hiyoshi M, Murono K, Ishihara S. Venous thromboembolism in colorectal surgery: Incidence, risk factors, and prophylaxis. Asian J Surg. 2019 Sep;42(9):863-873. doi: 10.1016/j.asjsur.2018.12.013.
  • Myles PS, Andrews S, Nicholson J, Lobo DN, Mythen M. Contemporary Approaches to Perioperative IV Fluid Therapy. World J Surg. 2017 Oct;41(10):2457-2463. doi: 10.1007/s00268-017-4055-y.
  • Matot I, Paskaleva R, Eid L, Cohen K, Khalaileh A, Elazary R, Keidar A. Effect of the volume of fluids administered on intraoperative oliguria in laparoscopic bariatric surgery: a randomized controlled trial. Arch Surg. 2012 Mar;147(3):228-34. doi: 10.1001/archsurg.2011.308.
  • Schreiber A, Aydil E, Walschus U, Glitsch A, Patrzyk M, Heidecke CD, Schulze T. Early removal of urinary drainage in patients receiving epidural analgesia after colorectal surgery within an ERAS protocol is feasible. Langenbecks Arch Surg. 2019 Nov;404(7):853-863. doi: 10.1007/s00423-019-01834-6.
  • Sammut R, Trapani J, Deguara J, Ravasi V. The effect of gum chewing on postoperative ileus in open colorectal surgery patients: A review. J Perioper Pract. 2021 Apr;31(4):132-139. doi: 10.1177/1750458920917015.
  • Andersen HK, Lewis SJ, Thomas S. Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004080. doi: 10.1002/14651858.CD004080.pub2. Update in: Cochrane Database Syst Rev. 2018 Oct 24;10:CD004080.
  • Fiore JF Jr, Castelino T, Pecorelli N, Niculiseanu P, Balvardi S, Hershorn O, Liberman S, Charlebois P, Stein B, Carli F, Mayo NE, Feldman LS. Ensuring Early Mobilization Within an Enhanced Recovery Program for Colorectal Surgery: A Randomized Controlled Trial. Ann Surg. 2017 Aug;266(2):223-231. doi: 10.1097/SLA.0000000000002114.